Thakshila Dharmasena MSc Candidate, Monaghan Lab E3Ks: Conserved multi-taskers Investigating the role of a family of multi-functional enzymes in Arabidopsis thaliana Phosphorylation and ubiquitination are two of the most ubiquitous protein modifications in cells. While phosphorylation is catalyzed by protein kinases, ubiquitination is catalyzed by three subsequent enzymes. In plant cells, there is a proven interplay between protein kinases and E3 ubiquitin ligases, the final enzyme of the ubiquitination series. Generally, protein kinases and E3 ligases are two separate proteins coded by two separate genes. I am interested in a group of unique proteins that contain both kinase and E3 ligase domains in a single protein, hence named ‘E3Ks’. In my study, I focused on understanding the molecular evolution, biochemical and biological functions of this fascinating group of proteins in the model plant Arabidopsis thaliana.
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