A Possible Association Between Insulin Regulation and Alzheimer’s Disease Alzheimer’s disease (AD) is a neurodegenerative disease which affects millions of people worldwide. This disease of ageing has been associated with amyloid-beta (Aβ) plaques and tauneurofibrillary tangles in the brain, causing symptoms such as confusion, memory loss, and
impaired cognitive abilities. It is well known that insulin is a key regulator in the ageing process, as well as many other bodily processes such as metabolism and fat storage. An association between insulin regulation and amyloid-beta plaque accumulation has been noted in C. elegans. This study uses C. elegans to investigate how decreased inulin signaling affects the deposition of human amyloid-beta in a transgenic worm strain, and phenotypes associated with Aβ expression. The findings from this study indicate the interaction between insulin and Aβ is complex, and research in this area is critical to determine possible therapeutic strategies for AD in the future. Comments are closed.
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April 2024
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